Drug interactions
Rifapentine + Tolterodine
Severity: Moderate
Rifapentine and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine induces CYP3A4 and other enzymes, which may lower tolterodine exposure. The effect is likely modest in most patients but could reduce efficacy in CYP2D6 poor metabolizers.
What this interaction means in plain words
Rifapentine and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rifapentine belongs to Anti Bacterial; Tolterodine belongs to Genitourinary.
Why it happens
Induction of CYP3A4 by rifapentine increases tolterodine clearance.
What to do
Monitor for loss of bladder symptom control and titrate tolterodine accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Rifapentine with Tolterodine?
MediHelp rates the interaction as moderate. Rifapentine and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine induces CYP3A4 and other enzymes, which may lower tolterodine exposure. The effect is likely modest in most patients but could reduce efficacy in CYP2D6 poor metabolizers.
How serious is the interaction between Rifapentine and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of bladder symptom control and titrate tolterodine accordingly.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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