Drug interactions
Rifapentine + Vincristine
Severity: Moderate
Rifapentine and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine is an inducer of CYP3A4 and may accelerate vincristine metabolism. This could lower vincristine exposure and reduce antitumor effect.
What this interaction means in plain words
Rifapentine and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rifapentine belongs to Anti Bacterial; Vincristine belongs to Oncology.
Why it happens
CYP3A4 induction by rifapentine increases vincristine clearance.
What to do
Avoid concurrent rifamycin use when alternatives exist. Otherwise monitor clinical response to vincristine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Rifapentine with Vincristine?
MediHelp rates the interaction as moderate. Rifapentine and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine is an inducer of CYP3A4 and may accelerate vincristine metabolism. This could lower vincristine exposure and reduce antitumor effect.
How serious is the interaction between Rifapentine and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent rifamycin use when alternatives exist. Otherwise monitor clinical response to vincristine.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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