Drug interactions
Rifapentine + Vinorelbine
Severity: Moderate
Rifapentine and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine induces CYP3A4, the main enzyme that clears vinorelbine, and may lower vinorelbine exposure. This could reduce antineoplastic effect, although the clinical magnitude has not been well characterised.
What this interaction means in plain words
Rifapentine and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rifapentine belongs to Anti Bacterial; Vinorelbine belongs to Oncology.
Why it happens
Induction of CYP3A4 (and possibly P-glycoprotein) by rifapentine increases vinorelbine metabolism.
What to do
Where possible use an alternative to rifapentine during vinorelbine therapy. If they must be combined, monitor for reduced tumour response and neutropenia pattern.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinorelbine
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Rifapentine with Vinorelbine?
MediHelp rates the interaction as moderate. Rifapentine and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine induces CYP3A4, the main enzyme that clears vinorelbine, and may lower vinorelbine exposure. This could reduce antineoplastic effect, although the clinical magnitude has not been well characterised.
How serious is the interaction between Rifapentine and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible use an alternative to rifapentine during vinorelbine therapy. If they must be combined, monitor for reduced tumour response and neutropenia pattern.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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