Drug interactions
Rifaximin + Vemurafenib
Severity: Minor
Rifaximin and Vemurafenib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib inhibits P-glycoprotein and may raise systemic rifaximin exposure. Because rifaximin is minimally absorbed, clinical consequences are likely small in most patients.
What this interaction means in plain words
Rifaximin and Vemurafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rifaximin belongs to Anti Bacterial; Vemurafenib belongs to Oncology.
Why it happens
Vemurafenib inhibits P-glycoprotein, decreasing rifaximin efflux.
What to do
No dose change is usually needed. Monitor for rifaximin adverse effects in patients with severe hepatic impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rifaximin
- Cholera vaccine + Rifaximin Major
- Microbiota + Rifaximin Major
- Amiodarone + Rifaximin Moderate
- Bcg intravesical live + Rifaximin Moderate
- Cyclosporine + Rifaximin Moderate
- Cyclosporin + Rifaximin Moderate
Other interactions of Vemurafenib
Frequently asked questions
Can I take Rifaximin with Vemurafenib?
MediHelp rates the interaction as minor. Rifaximin and Vemurafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vemurafenib inhibits P-glycoprotein and may raise systemic rifaximin exposure. Because rifaximin is minimally absorbed, clinical consequences are likely small in most patients.
How serious is the interaction between Rifaximin and Vemurafenib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor for rifaximin adverse effects in patients with severe hepatic impairment.
What other medicines interact with Rifaximin?
MediHelp also lists interactions of Rifaximin with, for example, Cholera vaccine, Microbiota, Amiodarone. The full list is on the Rifaximin page.
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