Drug interactions
Rimabotulinumtoxinb + Streptomycin
Severity: Moderate
Rimabotulinumtoxinb and Streptomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminoglycosides can impair neuromuscular transmission and may amplify the effect of botulinum toxin. This can lead to excessive or generalized muscle weakness, including swallowing and breathing difficulties.
What this interaction means in plain words
Rimabotulinumtoxinb and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rimabotulinumtoxinb belongs to Musculoskeletal; Streptomycin belongs to Anti Bacterial.
Why it happens
Additive neuromuscular blockade through reduced presynaptic acetylcholine release by aminoglycosides and botulinum toxin.
What to do
Avoid concurrent use where possible, or monitor closely for generalized weakness, dysphagia and respiratory compromise after injection. Delay toxin treatment if an aminoglycoside course is ongoing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Streptomycin
Other interactions of Rimabotulinumtoxinb
- Amikacin + Rimabotulinumtoxinb Moderate
- Amitriptyline + Rimabotulinumtoxinb Moderate
- Atracurium + Rimabotulinumtoxinb Moderate
- Atropine + Rimabotulinumtoxinb Moderate
- Baclofen + Rimabotulinumtoxinb Moderate
- Benztropine + Rimabotulinumtoxinb Moderate
Frequently asked questions
Can I take Rimabotulinumtoxinb with Streptomycin?
MediHelp rates the interaction as moderate. Rimabotulinumtoxinb and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminoglycosides can impair neuromuscular transmission and may amplify the effect of botulinum toxin. This can lead to excessive or generalized muscle weakness, including swallowing and breathing difficulties.
How serious is the interaction between Rimabotulinumtoxinb and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible, or monitor closely for generalized weakness, dysphagia and respiratory compromise after injection. Delay toxin treatment if an aminoglycoside course is ongoing.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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