Drug interactions
Rimabotulinumtoxinb + Tolterodine
Severity: Moderate
Rimabotulinumtoxinb and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rimabotulinumtoxin B causes cholinergic blockade, and anticholinergic drugs may add to this. Systemic anticholinergic effects such as dry mouth, and rarely neuromuscular weakness, may be increased.
What this interaction means in plain words
Rimabotulinumtoxinb and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rimabotulinumtoxinb belongs to Musculoskeletal; Tolterodine belongs to Genitourinary.
Why it happens
Additive cholinergic blockade at muscarinic receptors and neuromuscular junction.
What to do
Monitor for generalized weakness, dysphagia and respiratory symptoms after injection. Consider reducing tolterodine if anticholinergic effects increase.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Rimabotulinumtoxinb and Tolterodine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tolterodine
Other interactions of Rimabotulinumtoxinb
- Amikacin + Rimabotulinumtoxinb Moderate
- Amitriptyline + Rimabotulinumtoxinb Moderate
- Atracurium + Rimabotulinumtoxinb Moderate
- Atropine + Rimabotulinumtoxinb Moderate
- Baclofen + Rimabotulinumtoxinb Moderate
- Benztropine + Rimabotulinumtoxinb Moderate
Frequently asked questions
Can I take Rimabotulinumtoxinb with Tolterodine?
MediHelp rates the interaction as moderate. Rimabotulinumtoxinb and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rimabotulinumtoxin B causes cholinergic blockade, and anticholinergic drugs may add to this. Systemic anticholinergic effects such as dry mouth, and rarely neuromuscular weakness, may be increased.
How serious is the interaction between Rimabotulinumtoxinb and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for generalized weakness, dysphagia and respiratory symptoms after injection. Consider reducing tolterodine if anticholinergic effects increase.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
