Drug interactions
Rimegepant + Sofosbuvir / velpatasvir
Severity: Moderate
Rimegepant and Sofosbuvir / velpatasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir inhibits P-glycoprotein and may increase rimegepant absorption and exposure. The clinical effect is likely modest but may increase side effects.
What this interaction means in plain words
Rimegepant and Sofosbuvir / velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Velpatasvir inhibits intestinal P-gp efflux of rimegepant, increasing its bioavailability.
What to do
Avoid a second rimegepant dose within 48 hours when taken with P-gp inhibitors, as labeling advises, and monitor for adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Rimegepant and Sofosbuvir / velpatasvir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Rimegepant
Frequently asked questions
Can I take Rimegepant with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as moderate. Rimegepant and Sofosbuvir / velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Velpatasvir inhibits P-glycoprotein and may increase rimegepant absorption and exposure. The clinical effect is likely modest but may increase side effects.
How serious is the interaction between Rimegepant and Sofosbuvir / velpatasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid a second rimegepant dose within 48 hours when taken with P-gp inhibitors, as labeling advises, and monitor for adverse effects.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
