Drug interactions
Rimegepant + Telotristat ethyl
Severity: Moderate
Rimegepant and Telotristat ethyl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telotristat ethyl can reduce exposure to CYP3A4 substrates. Rimegepant levels may fall and migraine efficacy may be reduced.
What this interaction means in plain words
Rimegepant and Telotristat ethyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Telotristat appears to induce CYP3A4, increasing rimegepant metabolism.
What to do
Monitor for reduced migraine control, and consider an alternative acute treatment if response is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rimegepant
Frequently asked questions
Can I take Rimegepant with Telotristat ethyl?
MediHelp rates the interaction as moderate. Rimegepant and Telotristat ethyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Telotristat ethyl can reduce exposure to CYP3A4 substrates. Rimegepant levels may fall and migraine efficacy may be reduced.
How serious is the interaction between Rimegepant and Telotristat ethyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced migraine control, and consider an alternative acute treatment if response is lost.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
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