Drug interactions
Riociguat + Safinamide
Severity: Moderate
Riociguat and Safinamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Safinamide may inhibit intestinal BCRP, and riociguat is a BCRP substrate, so riociguat exposure may rise. Because riociguat lowers blood pressure, higher exposure could cause symptomatic hypotension.
What this interaction means in plain words
Riociguat and Safinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Riociguat belongs to Cardiovascular; Safinamide belongs to Central Nervous System.
Why it happens
Inhibition of intestinal BCRP efflux by safinamide may increase riociguat absorption.
What to do
Monitor blood pressure and symptoms of hypotension when starting safinamide. Reduce the riociguat dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Other interactions of Riociguat
- Avanafil + Riociguat Contraindicated
- Dipyridamole + Riociguat Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Riociguat + Sildenafil Contraindicated
Frequently asked questions
Can I take Riociguat with Safinamide?
MediHelp rates the interaction as moderate. Riociguat and Safinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Safinamide may inhibit intestinal BCRP, and riociguat is a BCRP substrate, so riociguat exposure may rise. Because riociguat lowers blood pressure, higher exposure could cause symptomatic hypotension.
How serious is the interaction between Riociguat and Safinamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of hypotension when starting safinamide. Reduce the riociguat dose if hypotension occurs.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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