Drug interactions
Riociguat + Sunitinib
Severity: Minor
Riociguat and Sunitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sunitinib is not a strong CYP3A4 or P-gp inhibitor, so a meaningful rise in riociguat exposure is not well established. Any increase could add to riociguat-related hypotension.
What this interaction means in plain words
Riociguat and Sunitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Riociguat belongs to Cardiovascular; Sunitinib belongs to Oncology.
Why it happens
Possible weak inhibition of CYP or P-gp pathways by sunitinib; effect not well established.
What to do
Monitor blood pressure when starting or adjusting either drug. Reduce riociguat dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Other interactions of Riociguat
- Avanafil + Riociguat Contraindicated
- Dipyridamole + Riociguat Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Riociguat + Sildenafil Contraindicated
Frequently asked questions
Can I take Riociguat with Sunitinib?
MediHelp rates the interaction as minor. Riociguat and Sunitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sunitinib is not a strong CYP3A4 or P-gp inhibitor, so a meaningful rise in riociguat exposure is not well established. Any increase could add to riociguat-related hypotension.
How serious is the interaction between Riociguat and Sunitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting or adjusting either drug. Reduce riociguat dose if symptomatic hypotension occurs.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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