Drug interactions
Riociguat + Tamoxifen
Severity: Moderate
Riociguat and Tamoxifen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tamoxifen may modestly inhibit enzymes involved in riociguat clearance. This could raise riociguat levels and the risk of hypotension, though tamoxifen is not a strong inhibitor.
What this interaction means in plain words
Riociguat and Tamoxifen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Riociguat belongs to Cardiovascular; Tamoxifen belongs to Endocrine.
Why it happens
Possible weak inhibition of CYP-mediated riociguat metabolism.
What to do
Monitor blood pressure and symptoms of hypotension when starting or stopping tamoxifen. Adjust the riociguat dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamoxifen
- Amiodarone + Tamoxifen Major
- Anastrozole + Tamoxifen Major
- Bupropion + Tamoxifen Major
- Carbamazepine + Tamoxifen Major
- Cinacalcet + Tamoxifen Major
- Dacomitinib + Tamoxifen Major
Other interactions of Riociguat
- Avanafil + Riociguat Contraindicated
- Dipyridamole + Riociguat Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Riociguat + Sildenafil Contraindicated
Frequently asked questions
Can I take Riociguat with Tamoxifen?
MediHelp rates the interaction as moderate. Riociguat and Tamoxifen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tamoxifen may modestly inhibit enzymes involved in riociguat clearance. This could raise riociguat levels and the risk of hypotension, though tamoxifen is not a strong inhibitor.
How serious is the interaction between Riociguat and Tamoxifen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of hypotension when starting or stopping tamoxifen. Adjust the riociguat dose if needed.
What other medicines interact with Tamoxifen?
MediHelp also lists interactions of Tamoxifen with, for example, Amiodarone, Anastrozole, Bupropion. The full list is on the Tamoxifen page.
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