Drug interactions
Risedronate + Voclosporin
Severity: Moderate
Risedronate and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin can cause dose-related nephrotoxicity, and risedronate is renally eliminated and can accumulate if kidney function declines. Together they may add to renal risk, particularly with reduced baseline kidney function.
What this interaction means in plain words
Risedronate and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Risedronate belongs to Musculoskeletal; Voclosporin belongs to Miscellaneous.
Why it happens
Additive nephrotoxic potential, with reduced renal clearance of risedronate if renal function falls.
What to do
Monitor serum creatinine and eGFR regularly and avoid risedronate if creatinine clearance falls below its labeled threshold.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risedronate
- Aluminum hydroxide + Risedronate Moderate
- Calcium acetate + Risedronate Moderate
- Calcium carbonate + Risedronate Moderate
- Calcium chloride + Risedronate Moderate
- Calcium citrate + Risedronate Moderate
- Calcium gluconate + Risedronate Moderate
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Risedronate with Voclosporin?
MediHelp rates the interaction as moderate. Risedronate and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin can cause dose-related nephrotoxicity, and risedronate is renally eliminated and can accumulate if kidney function declines. Together they may add to renal risk, particularly with reduced baseline kidney function.
How serious is the interaction between Risedronate and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and eGFR regularly and avoid risedronate if creatinine clearance falls below its labeled threshold.
What other medicines interact with Risedronate?
MediHelp also lists interactions of Risedronate with, for example, Aluminum hydroxide, Calcium acetate, Calcium carbonate. The full list is on the Risedronate page.
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