Drug interactions
Ritlecitinib + Theophylline
Severity: Moderate
Ritlecitinib and Theophylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritlecitinib inhibits CYP1A2 and CYP3A4 in vitro and may increase exposure to theophylline. Theophylline has a narrow therapeutic index so accumulation could cause nausea, tachycardia, arrhythmias or seizures.
What this interaction means in plain words
Ritlecitinib and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ritlecitinib belongs to Oncology; Theophylline belongs to Respiratory.
Why it happens
Inhibition of CYP1A2 and CYP3A4 reduces theophylline clearance.
What to do
Monitor theophylline serum concentrations and toxicity symptoms after ritlecitinib is started, and reduce the theophylline dose if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Ritlecitinib
Frequently asked questions
Can I take Ritlecitinib with Theophylline?
MediHelp rates the interaction as moderate. Ritlecitinib and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritlecitinib inhibits CYP1A2 and CYP3A4 in vitro and may increase exposure to theophylline. Theophylline has a narrow therapeutic index so accumulation could cause nausea, tachycardia, arrhythmias or seizures.
How serious is the interaction between Ritlecitinib and Theophylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor theophylline serum concentrations and toxicity symptoms after ritlecitinib is started, and reduce the theophylline dose if levels rise.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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