Drug interactions
Ritonavir + Sorafenib
Severity: Minor
Ritonavir and Sorafenib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir strongly inhibits CYP3A4 and may raise sorafenib levels. Because a strong CYP3A4 inhibitor did not substantially change sorafenib exposure in a study, the effect is probably limited.
What this interaction means in plain words
Ritonavir and Sorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ritonavir belongs to Anti Virals; Sorafenib belongs to Oncology.
Why it happens
Ritonavir inhibits CYP3A4-mediated sorafenib metabolism.
What to do
No routine dose change is needed. Monitor for sorafenib adverse effects such as diarrhea and skin reactions.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sorafenib
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Ritonavir with Sorafenib?
MediHelp rates the interaction as minor. Ritonavir and Sorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ritonavir strongly inhibits CYP3A4 and may raise sorafenib levels. Because a strong CYP3A4 inhibitor did not substantially change sorafenib exposure in a study, the effect is probably limited.
How serious is the interaction between Ritonavir and Sorafenib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for sorafenib adverse effects such as diarrhea and skin reactions.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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