Drug interactions
Ritonavir + Timolol
Severity: Moderate
Ritonavir and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir inhibits CYP2D6 and can raise timolol concentrations. This increases the risk of bradycardia, hypotension, AV block and PR prolongation.
What this interaction means in plain words
Ritonavir and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ritonavir belongs to Anti Virals; Timolol belongs to Cardiovascular.
Why it happens
Inhibition of CYP2D6 by ritonavir decreases the hepatic metabolism of timolol.
What to do
Monitor heart rate, blood pressure and ECG, and lower the timolol dose if bradycardia or conduction delay occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Ritonavir with Timolol?
MediHelp rates the interaction as moderate. Ritonavir and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir inhibits CYP2D6 and can raise timolol concentrations. This increases the risk of bradycardia, hypotension, AV block and PR prolongation.
How serious is the interaction between Ritonavir and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG, and lower the timolol dose if bradycardia or conduction delay occurs.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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