Drug interactions
Ritonavir + Tobramycin
Severity: Minor
Ritonavir and Tobramycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir inhibits P-glycoprotein, but tobramycin is not a clinically relevant substrate and is cleared renally. No important change in tobramycin exposure is expected.
What this interaction means in plain words
Ritonavir and Tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ritonavir belongs to Anti Virals; Tobramycin belongs to Anti Bacterial.
Why it happens
Theoretical P-glycoprotein inhibition; no established clinical effect.
What to do
No adjustment is needed; monitor tobramycin levels and renal function as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Ritonavir with Tobramycin?
MediHelp rates the interaction as minor. Ritonavir and Tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ritonavir inhibits P-glycoprotein, but tobramycin is not a clinically relevant substrate and is cleared renally. No important change in tobramycin exposure is expected.
How serious is the interaction between Ritonavir and Tobramycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed; monitor tobramycin levels and renal function as usual.
What other medicines interact with Tobramycin?
MediHelp also lists interactions of Tobramycin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Tobramycin page.
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