Drug interactions
Ritonavir + Trabectedin
Severity: Major
Ritonavir and Trabectedin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir increases trabectedin exposure and may heighten the risk of myelosuppression, hepatotoxicity and rhabdomyolysis.
What this interaction means in plain words
Ritonavir and Trabectedin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ritonavir belongs to Anti Virals; Trabectedin belongs to Oncology.
Why it happens
Strong CYP3A4 inhibition by ritonavir reduces trabectedin clearance.
What to do
Avoid concomitant use. If short-term use is unavoidable, monitor liver enzymes, CK and blood counts closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Trabectedin
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Ritonavir with Trabectedin?
MediHelp rates the interaction as major. Ritonavir and Trabectedin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir increases trabectedin exposure and may heighten the risk of myelosuppression, hepatotoxicity and rhabdomyolysis.
How serious is the interaction between Ritonavir and Trabectedin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use. If short-term use is unavoidable, monitor liver enzymes, CK and blood counts closely.
What other medicines interact with Trabectedin?
MediHelp also lists interactions of Trabectedin with, for example, Apalutamide, Carbamazepine, Chloramphenicol. The full list is on the Trabectedin page.
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