Drug interactions
Ritonavir + Vinorelbine
Severity: Major
Ritonavir and Vinorelbine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir is a strong CYP3A4 inhibitor and may raise vinorelbine concentrations. This can intensify myelosuppression, neurotoxicity and constipation or ileus.
What this interaction means in plain words
Ritonavir and Vinorelbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ritonavir belongs to Anti Virals; Vinorelbine belongs to Oncology.
Why it happens
Ritonavir inhibits CYP3A4 and P-glycoprotein, reducing vinorelbine clearance.
What to do
Avoid the combination if an alternative antiretroviral is possible. Otherwise monitor blood counts closely and consider reducing the vinorelbine dose, watching for neuropathy and bowel toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vinorelbine
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Ritonavir with Vinorelbine?
MediHelp rates the interaction as major. Ritonavir and Vinorelbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir is a strong CYP3A4 inhibitor and may raise vinorelbine concentrations. This can intensify myelosuppression, neurotoxicity and constipation or ileus.
How serious is the interaction between Ritonavir and Vinorelbine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative antiretroviral is possible. Otherwise monitor blood counts closely and consider reducing the vinorelbine dose, watching for neuropathy and bowel toxicity.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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