Drug interactions
Rivaroxaban + Saw palmetto
Severity: Minor
Rivaroxaban and Saw palmetto: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saw palmetto has been linked in case reports to increased bleeding, and may add to the hemorrhagic risk of rivaroxaban. The evidence is limited and the mechanism is uncertain.
What this interaction means in plain words
Rivaroxaban and Saw palmetto have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rivaroxaban belongs to Cardiovascular; Saw palmetto belongs to Gastrointestinal Tract.
Why it happens
Mechanism not established; possible mild antiplatelet effect.
What to do
Ask patients about herbal use and advise monitoring for bruising or bleeding. Consider stopping the supplement if bleeding occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Other interactions of Saw palmetto
- Aspirin rectal + Saw palmetto Moderate
- Aspirin + Saw palmetto Moderate
- Dabigatran + Saw palmetto Moderate
- Desirudin + Saw palmetto Moderate
- Ketorolac + Saw palmetto Moderate
- Meclofenamate + Saw palmetto Moderate
Frequently asked questions
Can I take Rivaroxaban with Saw palmetto?
MediHelp rates the interaction as minor. Rivaroxaban and Saw palmetto have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Saw palmetto has been linked in case reports to increased bleeding, and may add to the hemorrhagic risk of rivaroxaban. The evidence is limited and the mechanism is uncertain.
How serious is the interaction between Rivaroxaban and Saw palmetto?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask patients about herbal use and advise monitoring for bruising or bleeding. Consider stopping the supplement if bleeding occurs.
What other medicines interact with Rivaroxaban?
MediHelp also lists interactions of Rivaroxaban with, for example, Defibrotide, Ketoconazole, Ketorolac. The full list is on the Rivaroxaban page.
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