Drug interactions
Rivastigmine + Solifenacin
Severity: Moderate
Rivastigmine and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rivastigmine raises acetylcholine levels while solifenacin blocks muscarinic receptors, so they counteract each other. The result can be reduced cognitive benefit from rivastigmine, and antimuscarinics are generally discouraged in patients with dementia.
What this interaction means in plain words
Rivastigmine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rivastigmine belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
Pharmacodynamic antagonism between a cholinesterase inhibitor and an antimuscarinic.
What to do
Avoid the combination where possible and consider non-pharmacological or non-anticholinergic options for bladder symptoms. If it is used, monitor cognition and urinary symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Rivastigmine
Frequently asked questions
Can I take Rivastigmine with Solifenacin?
MediHelp rates the interaction as moderate. Rivastigmine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rivastigmine raises acetylcholine levels while solifenacin blocks muscarinic receptors, so they counteract each other. The result can be reduced cognitive benefit from rivastigmine, and antimuscarinics are generally discouraged in patients with dementia.
How serious is the interaction between Rivastigmine and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and consider non-pharmacological or non-anticholinergic options for bladder symptoms. If it is used, monitor cognition and urinary symptoms.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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