Drug interactions
Ropeginterferon alfa 2b + Tacrolimus
Severity: Moderate
Ropeginterferon alfa 2b and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Interferons can cause myelosuppression and tacrolimus may add to hematologic toxicity. Interferons may also provoke graft rejection in transplant patients.
What this interaction means in plain words
Ropeginterferon alfa 2b and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive myelosuppression and immunomodulatory effects.
What to do
Monitor complete blood counts regularly and reduce or hold ropeginterferon if cytopenias occur. Check tacrolimus levels and graft function in transplant recipients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ropeginterferon alfa 2b and Tacrolimus, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Ropeginterferon alfa 2b with Tacrolimus?
MediHelp rates the interaction as moderate. Ropeginterferon alfa 2b and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Interferons can cause myelosuppression and tacrolimus may add to hematologic toxicity. Interferons may also provoke graft rejection in transplant patients.
How serious is the interaction between Ropeginterferon alfa 2b and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and reduce or hold ropeginterferon if cytopenias occur. Check tacrolimus levels and graft function in transplant recipients.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
