Drug interactions
Ropinirole + Thioridazine
Severity: Major
Ropinirole and Thioridazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine blocks D2 dopamine receptors and counteracts ropinirole's agonist effect. This can worsen motor symptoms of Parkinson's disease or restless legs syndrome. Ropinirole may in turn aggravate psychotic symptoms.
What this interaction means in plain words
Ropinirole and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ropinirole belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at dopamine D2 receptors.
What to do
Avoid the combination. If an antipsychotic is required in Parkinson's disease, prefer quetiapine or clozapine.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Ropinirole
- Amisulpride + Ropinirole Contraindicated
- Chlorpromazine + Ropinirole Major
- Droperidol + Ropinirole Major
- Fluphenazine + Ropinirole Major
- Fluvoxamine + Ropinirole Major
- Haloperidol + Ropinirole Major
Frequently asked questions
Can I take Ropinirole with Thioridazine?
MediHelp rates the interaction as major. Ropinirole and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Thioridazine blocks D2 dopamine receptors and counteracts ropinirole's agonist effect. This can worsen motor symptoms of Parkinson's disease or restless legs syndrome. Ropinirole may in turn aggravate psychotic symptoms.
How serious is the interaction between Ropinirole and Thioridazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If an antipsychotic is required in Parkinson's disease, prefer quetiapine or clozapine.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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