Drug interactions
Ropinirole + Ziprasidone
Severity: Major
Ropinirole and Ziprasidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone blocks dopamine D2 receptors and counteracts the agonist effect of ropinirole. Loss of motor control or worsening of restless legs symptoms may occur.
What this interaction means in plain words
Ropinirole and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ropinirole belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between a D2 receptor antagonist and a D2/D3 receptor agonist.
What to do
Avoid the combination; prefer quetiapine or clozapine in Parkinson's disease psychosis. Monitor motor function if co-use is necessary.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Ropinirole
- Amisulpride + Ropinirole Contraindicated
- Chlorpromazine + Ropinirole Major
- Droperidol + Ropinirole Major
- Fluphenazine + Ropinirole Major
- Fluvoxamine + Ropinirole Major
- Haloperidol + Ropinirole Major
Frequently asked questions
Can I take Ropinirole with Ziprasidone?
MediHelp rates the interaction as major. Ropinirole and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ziprasidone blocks dopamine D2 receptors and counteracts the agonist effect of ropinirole. Loss of motor control or worsening of restless legs symptoms may occur.
How serious is the interaction between Ropinirole and Ziprasidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; prefer quetiapine or clozapine in Parkinson's disease psychosis. Monitor motor function if co-use is necessary.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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