Drug interactions
Rosiglitazone + Sacubitril / valsartan
Severity: Minor
Rosiglitazone and Sacubitril / valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rosiglitazone is not an established OATP1B1 inhibitor, so a meaningful rise in valsartan exposure is not expected. A more relevant concern is that thiazolidinediones cause fluid retention, which matters in heart failure, the usual indication for sacubitril/valsartan.
What this interaction means in plain words
Rosiglitazone and Sacubitril / valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No clear pharmacokinetic mechanism is established; the transporter interaction is theoretical.
What to do
No dose change is needed for the transporter issue. Monitor weight and signs of fluid overload in patients with heart failure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Frequently asked questions
Can I take Rosiglitazone with Sacubitril / valsartan?
MediHelp rates the interaction as minor. Rosiglitazone and Sacubitril / valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rosiglitazone is not an established OATP1B1 inhibitor, so a meaningful rise in valsartan exposure is not expected. A more relevant concern is that thiazolidinediones cause fluid retention, which matters in heart failure, the usual indication for sacubitril/valsartan.
How serious is the interaction between Rosiglitazone and Sacubitril / valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed for the transporter issue. Monitor weight and signs of fluid overload in patients with heart failure.
What other medicines interact with Rosiglitazone?
MediHelp also lists interactions of Rosiglitazone with, for example, Insulin aspart protamine / insulin aspart, Insulin aspart-insulin aspart protamine, Insulin aspart. The full list is on the Rosiglitazone page.
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