Drug interactions
Rosiglitazone + Sage
Severity: Minor
Rosiglitazone and Sage: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sage extracts have shown glucose-lowering effects in some animal and small human studies. With rosiglitazone, additive glucose lowering is possible, with a theoretical risk of hypoglycemia.
What this interaction means in plain words
Rosiglitazone and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive hypoglycemic effect, potentially involving PPAR-gamma activity; not firmly established.
What to do
Monitor blood glucose if sage supplements or medicinal extracts are used regularly. Adjust the antidiabetic dose only if glucose falls.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Frequently asked questions
Can I take Rosiglitazone with Sage?
MediHelp rates the interaction as minor. Rosiglitazone and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sage extracts have shown glucose-lowering effects in some animal and small human studies. With rosiglitazone, additive glucose lowering is possible, with a theoretical risk of hypoglycemia.
How serious is the interaction between Rosiglitazone and Sage?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose if sage supplements or medicinal extracts are used regularly. Adjust the antidiabetic dose only if glucose falls.
What other medicines interact with Rosiglitazone?
MediHelp also lists interactions of Rosiglitazone with, for example, Insulin aspart protamine / insulin aspart, Insulin aspart-insulin aspart protamine, Insulin aspart. The full list is on the Rosiglitazone page.
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