Drug interactions
Rosiglitazone + Sulfamethoxypyridazine
Severity: Minor
Rosiglitazone and Sulfamethoxypyridazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfonamide antibacterials can occasionally lower blood glucose, and this may add to the effect of rosiglitazone. Hypoglycemia is uncommon with rosiglitazone alone but may be more likely when combined with other glucose-lowering agents.
What this interaction means in plain words
Rosiglitazone and Sulfamethoxypyridazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive hypoglycemic effect; sulfonamides may also inhibit CYP2C8, which metabolizes rosiglitazone, though this is not well established for this agent.
What to do
Monitor blood glucose when starting or stopping the sulfonamide, especially if the patient also takes insulin or a sulfonylurea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Rosiglitazone and Sulfamethoxypyridazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Frequently asked questions
Can I take Rosiglitazone with Sulfamethoxypyridazine?
MediHelp rates the interaction as minor. Rosiglitazone and Sulfamethoxypyridazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfonamide antibacterials can occasionally lower blood glucose, and this may add to the effect of rosiglitazone. Hypoglycemia is uncommon with rosiglitazone alone but may be more likely when combined with other glucose-lowering agents.
How serious is the interaction between Rosiglitazone and Sulfamethoxypyridazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping the sulfonamide, especially if the patient also takes insulin or a sulfonylurea.
What other medicines interact with Rosiglitazone?
MediHelp also lists interactions of Rosiglitazone with, for example, Insulin aspart protamine / insulin aspart, Insulin aspart-insulin aspart protamine, Insulin aspart. The full list is on the Rosiglitazone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
