Drug interactions
Rosuvastatin + Sodium bicarbonate
Severity: Minor
Rosuvastatin and Sodium bicarbonate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral antacids containing aluminium or magnesium lower rosuvastatin absorption; sodium bicarbonate is not clearly shown to do so. Any reduction would be modest and of limited clinical relevance.
What this interaction means in plain words
Rosuvastatin and Sodium bicarbonate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rosuvastatin belongs to Cardiovascular; Sodium bicarbonate belongs to Gastrointestinal Tract.
Why it happens
Possible reduction in rosuvastatin absorption due to altered gastric pH; mechanism is not well established for sodium bicarbonate.
What to do
Separating the doses by about 2 hours is a reasonable precaution. No other action is generally needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Rosuvastatin and Sodium bicarbonate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Rosuvastatin
Other interactions of Sodium bicarbonate
- Acetylsalicylic acid + Sodium bicarbonate Moderate
- Alendronate + Sodium bicarbonate Moderate
- Amantadine + Sodium bicarbonate Moderate
- Carbonyl iron + Sodium bicarbonate Moderate
- Cefditoren + Sodium bicarbonate Moderate
- Cefpodoxime + Sodium bicarbonate Moderate
Frequently asked questions
Can I take Rosuvastatin with Sodium bicarbonate?
MediHelp rates the interaction as minor. Rosuvastatin and Sodium bicarbonate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral antacids containing aluminium or magnesium lower rosuvastatin absorption; sodium bicarbonate is not clearly shown to do so. Any reduction would be modest and of limited clinical relevance.
How serious is the interaction between Rosuvastatin and Sodium bicarbonate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separating the doses by about 2 hours is a reasonable precaution. No other action is generally needed.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
