Drug interactions
Rosuvastatin + Sodium citrate / citric acid
Severity: Minor
Rosuvastatin and Sodium citrate / citric acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Citrate-based alkalinizing agents are not known to bind rosuvastatin, and no clear reduction in absorption has been established. Any effect is probably small.
What this interaction means in plain words
Rosuvastatin and Sodium citrate / citric acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible minor change in absorption through altered gastric pH; mechanism is not established.
What to do
Separate dosing by about 2 hours as a precaution. No further action is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rosuvastatin
Frequently asked questions
Can I take Rosuvastatin with Sodium citrate / citric acid?
MediHelp rates the interaction as minor. Rosuvastatin and Sodium citrate / citric acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Citrate-based alkalinizing agents are not known to bind rosuvastatin, and no clear reduction in absorption has been established. Any effect is probably small.
How serious is the interaction between Rosuvastatin and Sodium citrate / citric acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate dosing by about 2 hours as a precaution. No further action is needed.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
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