Drug interactions
Rosuvastatin + Sofosbuvir / velpatasvir
Severity: Major
Rosuvastatin and Sofosbuvir / velpatasvir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir increases rosuvastatin exposure markedly. This raises the risk of myopathy including rhabdomyolysis.
What this interaction means in plain words
Rosuvastatin and Sofosbuvir / velpatasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Velpatasvir inhibits BCRP and OATP1B transporters, increasing rosuvastatin absorption and reducing hepatic uptake.
What to do
Do not exceed rosuvastatin 10 mg daily with this combination, and monitor for muscle symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rosuvastatin
Frequently asked questions
Can I take Rosuvastatin with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as major. Rosuvastatin and Sofosbuvir / velpatasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Velpatasvir increases rosuvastatin exposure markedly. This raises the risk of myopathy including rhabdomyolysis.
How serious is the interaction between Rosuvastatin and Sofosbuvir / velpatasvir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not exceed rosuvastatin 10 mg daily with this combination, and monitor for muscle symptoms.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
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