Drug interactions
Rotavirus oral vaccine live + Sirolimus
Severity: Major
Rotavirus oral vaccine live and Sirolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Live attenuated vaccine replication may be uncontrolled in patients on sirolimus, raising the risk of vaccine-related infection, and the immune response may be poor. Live vaccines are generally avoided during immunosuppressive therapy.
What this interaction means in plain words
Rotavirus oral vaccine live and Sirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Sirolimus impairs lymphocyte-mediated control of live attenuated organisms and blunts vaccine response.
What to do
Avoid live vaccines during sirolimus therapy; give them at least several weeks before starting if possible. Seek specialist advice for infants exposed to maternal immunosuppression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Rotavirus oral vaccine live with Sirolimus?
MediHelp rates the interaction as major. Rotavirus oral vaccine live and Sirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Live attenuated vaccine replication may be uncontrolled in patients on sirolimus, raising the risk of vaccine-related infection, and the immune response may be poor. Live vaccines are generally avoided during immunosuppressive therapy.
How serious is the interaction between Rotavirus oral vaccine live and Sirolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during sirolimus therapy; give them at least several weeks before starting if possible. Seek specialist advice for infants exposed to maternal immunosuppression.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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