Drug interactions
Rotavirus oral vaccine live + Upadacitinib
Severity: Major
Rotavirus oral vaccine live and Upadacitinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Upadacitinib impairs immunity, so a live rotavirus vaccine could theoretically cause vaccine-strain infection. Relevance is mainly for infants exposed to the drug, for example through maternal treatment.
What this interaction means in plain words
Rotavirus oral vaccine live and Upadacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
JAK inhibition suppresses immune responses, permitting replication of live attenuated virus.
What to do
Avoid live vaccines in patients receiving upadacitinib. Follow current guidance on timing for infants with possible in utero or breast milk exposure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Upadacitinib
- Abrocitinib + Upadacitinib Contraindicated
- Adenovirus types 4 and 7 live + Upadacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Bcg vaccine live + Upadacitinib Contraindicated
- Cyclosporine + Upadacitinib Contraindicated
- Dengue vaccine + Upadacitinib Contraindicated
Frequently asked questions
Can I take Rotavirus oral vaccine live with Upadacitinib?
MediHelp rates the interaction as major. Rotavirus oral vaccine live and Upadacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Upadacitinib impairs immunity, so a live rotavirus vaccine could theoretically cause vaccine-strain infection. Relevance is mainly for infants exposed to the drug, for example through maternal treatment.
How serious is the interaction between Rotavirus oral vaccine live and Upadacitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines in patients receiving upadacitinib. Follow current guidance on timing for infants with possible in utero or breast milk exposure.
What other medicines interact with Upadacitinib?
MediHelp also lists interactions of Upadacitinib with, for example, Abrocitinib, Adenovirus types 4 and 7 live, Baricitinib. The full list is on the Upadacitinib page.
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