Drug interactions
Roxadustat + Sevelamer
Severity: Moderate
Roxadustat and Sevelamer: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevelamer reduces roxadustat absorption when taken together, lowering systemic exposure. This may weaken the hemoglobin response.
What this interaction means in plain words
Roxadustat and Sevelamer can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Roxadustat belongs to Miscellaneous; Sevelamer belongs to Miscellaneous.
Why it happens
Binding of roxadustat by sevelamer in the gastrointestinal tract, reducing absorption.
What to do
Take roxadustat at least 1 hour after sevelamer. Monitor hemoglobin and adjust the roxadustat dose to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Roxadustat
- Gemfibrozil + Roxadustat Major
- Probenecid + Roxadustat Major
- Atorvastatin + Roxadustat Moderate
- Calcium acetate + Roxadustat Moderate
- Calcium + Roxadustat Moderate
- Iron + Roxadustat Moderate
Other interactions of Sevelamer
- Carbamazepine + Sevelamer Moderate
- Ciprofloxacin + Sevelamer Moderate
- Dichlorphenamide + Sevelamer Moderate
- Erdafitinib + Sevelamer Moderate
- Gabapentin + Sevelamer Moderate
- Mycophenolic acid + Sevelamer Moderate
Frequently asked questions
Can I take Roxadustat with Sevelamer?
MediHelp rates the interaction as moderate. Roxadustat and Sevelamer can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevelamer reduces roxadustat absorption when taken together, lowering systemic exposure. This may weaken the hemoglobin response.
How serious is the interaction between Roxadustat and Sevelamer?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take roxadustat at least 1 hour after sevelamer. Monitor hemoglobin and adjust the roxadustat dose to response.
What other medicines interact with Roxadustat?
MediHelp also lists interactions of Roxadustat with, for example, Gemfibrozil, Probenecid, Atorvastatin. The full list is on the Roxadustat page.
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