Drug interactions
Atorvastatin + Roxadustat
Severity: Moderate
Atorvastatin and Roxadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Roxadustat raises atorvastatin exposure, which may increase statin-related adverse effects including myopathy and liver enzyme elevation.
What this interaction means in plain words
Atorvastatin and Roxadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Roxadustat belongs to Miscellaneous.
Why it happens
Roxadustat inhibits OATP1B1 and BCRP, decreasing hepatic uptake and efflux of atorvastatin.
What to do
Monitor for muscle symptoms and liver enzymes. Consider reducing the atorvastatin dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Roxadustat
- Gemfibrozil + Roxadustat Major
- Probenecid + Roxadustat Major
- Calcium acetate + Roxadustat Moderate
- Calcium + Roxadustat Moderate
- Iron + Roxadustat Moderate
- Magnesium + Roxadustat Moderate
Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Cyclosporine Major
Frequently asked questions
Can I take Atorvastatin with Roxadustat?
MediHelp rates the interaction as moderate. Atorvastatin and Roxadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Roxadustat raises atorvastatin exposure, which may increase statin-related adverse effects including myopathy and liver enzyme elevation.
How serious is the interaction between Atorvastatin and Roxadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle symptoms and liver enzymes. Consider reducing the atorvastatin dose.
What other medicines interact with Roxadustat?
MediHelp also lists interactions of Roxadustat with, for example, Gemfibrozil, Probenecid, Calcium acetate. The full list is on the Roxadustat page.
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