Drug interactions
Calcium + Roxadustat
Severity: Moderate
Calcium and Roxadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium supplements or calcium-containing products can bind roxadustat in the gut and lower its absorption. This may reduce its effect on hemoglobin.
What this interaction means in plain words
Calcium and Roxadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium belongs to Gastrointestinal Tract; Roxadustat belongs to Miscellaneous.
Why it happens
Chelation of roxadustat by calcium in the gastrointestinal tract, reducing absorption.
What to do
Take roxadustat at least 1 hour after calcium products. Monitor hemoglobin response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Roxadustat
- Gemfibrozil + Roxadustat Major
- Probenecid + Roxadustat Major
- Atorvastatin + Roxadustat Moderate
- Calcium acetate + Roxadustat Moderate
- Iron + Roxadustat Moderate
- Magnesium + Roxadustat Moderate
Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Frequently asked questions
Can I take Calcium with Roxadustat?
MediHelp rates the interaction as moderate. Calcium and Roxadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium supplements or calcium-containing products can bind roxadustat in the gut and lower its absorption. This may reduce its effect on hemoglobin.
How serious is the interaction between Calcium and Roxadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take roxadustat at least 1 hour after calcium products. Monitor hemoglobin response.
What other medicines interact with Roxadustat?
MediHelp also lists interactions of Roxadustat with, for example, Gemfibrozil, Probenecid, Atorvastatin. The full list is on the Roxadustat page.
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