Drug interactions
Iron + Roxadustat
Severity: Moderate
Iron and Roxadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral iron can bind roxadustat in the gut and reduce its absorption. This may lower roxadustat exposure and its effect on hemoglobin.
What this interaction means in plain words
Iron and Roxadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iron belongs to Gastrointestinal Tract; Roxadustat belongs to Miscellaneous.
Why it happens
Chelation of roxadustat by iron cations in the gastrointestinal tract, reducing absorption.
What to do
Take roxadustat at least 1 hour after oral iron products. Monitor hemoglobin and iron indices.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Iron and Roxadustat, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Roxadustat
- Gemfibrozil + Roxadustat Major
- Probenecid + Roxadustat Major
- Atorvastatin + Roxadustat Moderate
- Calcium acetate + Roxadustat Moderate
- Calcium + Roxadustat Moderate
- Magnesium + Roxadustat Moderate
Other interactions of Iron
- Acetohydroxamic acid + Iron Moderate
- Aluminum hydroxide + Iron Moderate
- Baloxavir marboxil + Iron Moderate
- Calcium acetate + Iron Moderate
- Calcium carbonate + Iron Moderate
- Calcium citrate + Iron Moderate
Frequently asked questions
Can I take Iron with Roxadustat?
MediHelp rates the interaction as moderate. Iron and Roxadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral iron can bind roxadustat in the gut and reduce its absorption. This may lower roxadustat exposure and its effect on hemoglobin.
How serious is the interaction between Iron and Roxadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take roxadustat at least 1 hour after oral iron products. Monitor hemoglobin and iron indices.
What other medicines interact with Roxadustat?
MediHelp also lists interactions of Roxadustat with, for example, Gemfibrozil, Probenecid, Atorvastatin. The full list is on the Roxadustat page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
