Drug interactions
Rozanolixizumab + Trastuzumab
Severity: Moderate
Rozanolixizumab and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rozanolixizumab blocks the neonatal Fc receptor, which recycles IgG, and so lowers circulating IgG levels. Trastuzumab is an IgG1 antibody, so its exposure and efficacy may be reduced.
What this interaction means in plain words
Rozanolixizumab and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rozanolixizumab belongs to Miscellaneous; Trastuzumab belongs to Oncology.
Why it happens
FcRn blockade increases catabolism of IgG-based drugs such as trastuzumab.
What to do
Monitor for reduced trastuzumab response. If trastuzumab treatment is essential long term, consider alternatives to rozanolixizumab.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trastuzumab
Other interactions of Rozanolixizumab
- Rozanolixizumab + Upadacitinib Major
- Abatacept + Rozanolixizumab Moderate
- Adalimumab + Rozanolixizumab Moderate
- Ado-trastuzumab + Rozanolixizumab Moderate
- Basiliximab + Rozanolixizumab Moderate
- Bevacizumab + Rozanolixizumab Moderate
Frequently asked questions
Can I take Rozanolixizumab with Trastuzumab?
MediHelp rates the interaction as moderate. Rozanolixizumab and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rozanolixizumab blocks the neonatal Fc receptor, which recycles IgG, and so lowers circulating IgG levels. Trastuzumab is an IgG1 antibody, so its exposure and efficacy may be reduced.
How serious is the interaction between Rozanolixizumab and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced trastuzumab response. If trastuzumab treatment is essential long term, consider alternatives to rozanolixizumab.
What other medicines interact with Trastuzumab?
MediHelp also lists interactions of Trastuzumab with, for example, Daunorubicin, Doxorubicin liposomal, Doxorubicin. The full list is on the Trastuzumab page.
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