Drug interactions
Bevacizumab + Rozanolixizumab
Severity: Moderate
Bevacizumab and Rozanolixizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rozanolixizumab blocks the neonatal Fc receptor and lowers circulating IgG, so it may shorten the half-life of IgG antibodies like bevacizumab and reduce their effect.
What this interaction means in plain words
Bevacizumab and Rozanolixizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bevacizumab belongs to Oncology; Rozanolixizumab belongs to Miscellaneous.
Why it happens
FcRn blockade reduces IgG recycling and increases catabolism of IgG monoclonal antibodies.
What to do
Monitor for reduced bevacizumab efficacy; if prolonged bevacizumab therapy is essential, consider alternatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bevacizumab
- Bevacizumab + Sunitinib Major
- Bevacizumab + Daunorubicin Moderate
- Bevacizumab + Dengue vaccine Moderate
- Bevacizumab + Doxorubicin Moderate
- Bevacizumab + Doxorubicin liposomal Moderate
- Bevacizumab + Efgartigimod / hyaluronidase sc Moderate
Other interactions of Rozanolixizumab
- Rozanolixizumab + Upadacitinib Major
- Abatacept + Rozanolixizumab Moderate
- Adalimumab + Rozanolixizumab Moderate
- Ado-trastuzumab + Rozanolixizumab Moderate
- Basiliximab + Rozanolixizumab Moderate
- Denosumab + Rozanolixizumab Moderate
Frequently asked questions
Can I take Bevacizumab with Rozanolixizumab?
MediHelp rates the interaction as moderate. Bevacizumab and Rozanolixizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rozanolixizumab blocks the neonatal Fc receptor and lowers circulating IgG, so it may shorten the half-life of IgG antibodies like bevacizumab and reduce their effect.
How serious is the interaction between Bevacizumab and Rozanolixizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced bevacizumab efficacy; if prolonged bevacizumab therapy is essential, consider alternatives.
What other medicines interact with Bevacizumab?
MediHelp also lists interactions of Bevacizumab with, for example, Sunitinib, Daunorubicin, Dengue vaccine. The full list is on the Bevacizumab page.
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