Drug interactions
Rubella vaccine + Tacrolimus
Severity: Contraindicated
Rubella vaccine and Tacrolimus: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rubella vaccine is a live attenuated virus. Tacrolimus may allow uncontrolled replication of the vaccine virus and reduces the immune response.
What this interaction means in plain words
Rubella vaccine and Tacrolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Calcineurin inhibition impairs cellular immunity against replication of live attenuated virus.
What to do
Avoid rubella vaccination during tacrolimus therapy. Vaccinate before immunosuppression and check serologic immunity.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Rubella vaccine with Tacrolimus?
MediHelp rates the interaction as contraindicated. Rubella vaccine and Tacrolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rubella vaccine is a live attenuated virus. Tacrolimus may allow uncontrolled replication of the vaccine virus and reduces the immune response.
How serious is the interaction between Rubella vaccine and Tacrolimus?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid rubella vaccination during tacrolimus therapy. Vaccinate before immunosuppression and check serologic immunity.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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