Drug interactions
Rufinamide + Ziprasidone
Severity: Minor
Rufinamide and Ziprasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rufinamide is a weak CYP3A4 inducer and may slightly reduce ziprasidone levels. The clinical significance is likely small.
What this interaction means in plain words
Rufinamide and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rufinamide belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Rufinamide weakly induces CYP3A4, increasing the metabolism of ziprasidone.
What to do
Monitor the psychiatric response when rufinamide is started or stopped. Increase ziprasidone only if symptoms emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Rufinamide and Ziprasidone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Rufinamide
- Carbamazepine + Rufinamide Moderate
- Desogestrel-ethinyl estradiol + Rufinamide Moderate
- Dronedarone + Rufinamide Moderate
- Esketamine + Rufinamide Moderate
- Ethinyl estradiol-drospirenone + Rufinamide Moderate
- Ethinyl estradiol-levonorgestrel + Rufinamide Moderate
Frequently asked questions
Can I take Rufinamide with Ziprasidone?
MediHelp rates the interaction as minor. Rufinamide and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rufinamide is a weak CYP3A4 inducer and may slightly reduce ziprasidone levels. The clinical significance is likely small.
How serious is the interaction between Rufinamide and Ziprasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the psychiatric response when rufinamide is started or stopped. Increase ziprasidone only if symptoms emerge.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
