Drug interactions
Saccharomyces boulardii + Voriconazole
Severity: Moderate
Saccharomyces boulardii and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saccharomyces boulardii is a live yeast, and systemic antifungals such as voriconazole may reduce its viability and probiotic effect. There is also a rare risk of fungemia from the yeast in immunocompromised patients.
What this interaction means in plain words
Saccharomyces boulardii and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antifungal activity of voriconazole against the live yeast organism.
What to do
Avoid the probiotic during voriconazole therapy, especially in immunocompromised or critically ill patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Saccharomyces boulardii with Voriconazole?
MediHelp rates the interaction as moderate. Saccharomyces boulardii and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Saccharomyces boulardii is a live yeast, and systemic antifungals such as voriconazole may reduce its viability and probiotic effect. There is also a rare risk of fungemia from the yeast in immunocompromised patients.
How serious is the interaction between Saccharomyces boulardii and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the probiotic during voriconazole therapy, especially in immunocompromised or critically ill patients.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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