Drug interactions
Sacubitril-valsartan + Simvastatin
Severity: Minor
Sacubitril-valsartan and Simvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan is taken up into the liver by OATP1B1, and simvastatin (mainly as its acid form) may compete for this transporter. Any rise in valsartan exposure is expected to be small and is unlikely to matter for most patients.
What this interaction means in plain words
Sacubitril-valsartan and Simvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sacubitril-valsartan belongs to Cardiovascular; Simvastatin belongs to Cardiovascular.
Why it happens
Possible competition at the hepatic OATP1B1 uptake transporter, based mainly on in vitro data.
What to do
No routine dose change is needed; check blood pressure and renal function as part of normal follow-up after starting either drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Sacubitril-valsartan and Simvastatin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Frequently asked questions
Can I take Sacubitril-valsartan with Simvastatin?
MediHelp rates the interaction as minor. Sacubitril-valsartan and Simvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valsartan is taken up into the liver by OATP1B1, and simvastatin (mainly as its acid form) may compete for this transporter. Any rise in valsartan exposure is expected to be small and is unlikely to matter for most patients.
How serious is the interaction between Sacubitril-valsartan and Simvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; check blood pressure and renal function as part of normal follow-up after starting either drug.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
