Drug interactions
Sacubitril-valsartan + Sparsentan
Severity: Contraindicated
Sacubitril-valsartan and Sparsentan: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan is a dual endothelin and angiotensin II receptor antagonist, so adding the valsartan component of sacubitril-valsartan duplicates angiotensin receptor blockade. This raises the risk of hypotension, syncope, hyperkalemia and deterioration of renal function, including acute kidney injury.
What this interaction means in plain words
Sacubitril-valsartan and Sparsentan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Sacubitril-valsartan belongs to Cardiovascular; Sparsentan belongs to Genitourinary.
Why it happens
Additive pharmacodynamic blockade of the angiotensin II type 1 receptor, with combined effects on blood pressure, potassium and renal hemodynamics.
What to do
Do not combine; sparsentan labeling contraindicates concomitant ARBs, ACE inhibitors and other RAAS agents. Stop one agent before starting the other, using a washout in line with the product labeling.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Sacubitril-valsartan with Sparsentan?
MediHelp rates the interaction as contraindicated. Sacubitril-valsartan and Sparsentan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sparsentan is a dual endothelin and angiotensin II receptor antagonist, so adding the valsartan component of sacubitril-valsartan duplicates angiotensin receptor blockade. This raises the risk of hypotension, syncope, hyperkalemia and deterioration of renal function, including acute kidney injury.
How serious is the interaction between Sacubitril-valsartan and Sparsentan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; sparsentan labeling contraindicates concomitant ARBs, ACE inhibitors and other RAAS agents. Stop one agent before starting the other, using a washout in line with the product labeling.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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