Drug interactions
Sacubitril-valsartan + Sulindac
Severity: Moderate
Sacubitril-valsartan and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as sulindac reduce renal prostaglandin synthesis, which can blunt the antihypertensive effect of sacubitril-valsartan and impair renal function, especially in elderly or volume-depleted patients. Hyperkalemia may also be more likely.
What this interaction means in plain words
Sacubitril-valsartan and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sacubitril-valsartan belongs to Cardiovascular; Sulindac belongs to Musculoskeletal.
Why it happens
NSAID inhibition of vasodilatory renal prostaglandins combined with angiotensin receptor blockade reduces glomerular filtration and potassium excretion and antagonizes blood pressure control.
What to do
Avoid regular NSAID use where possible; if needed, use the lowest dose for the shortest time and monitor blood pressure, creatinine and potassium, ensuring adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Sacubitril-valsartan with Sulindac?
MediHelp rates the interaction as moderate. Sacubitril-valsartan and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as sulindac reduce renal prostaglandin synthesis, which can blunt the antihypertensive effect of sacubitril-valsartan and impair renal function, especially in elderly or volume-depleted patients. Hyperkalemia may also be more likely.
How serious is the interaction between Sacubitril-valsartan and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use where possible; if needed, use the lowest dose for the shortest time and monitor blood pressure, creatinine and potassium, ensuring adequate hydration.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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