Drug interactions
Sacubitril / valsartan + Tizanidine
Severity: Moderate
Sacubitril / valsartan and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents lower blood pressure, so together they may cause symptomatic hypotension, particularly at initiation or dose increases. Patients with volume depletion or renal impairment are at higher risk.
What this interaction means in plain words
Sacubitril / valsartan and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antihypertensive pharmacodynamic effects.
What to do
Monitor blood pressure and renal function, and titrate each drug slowly. Reduce the tizanidine dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Frequently asked questions
Can I take Sacubitril / valsartan with Tizanidine?
MediHelp rates the interaction as moderate. Sacubitril / valsartan and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents lower blood pressure, so together they may cause symptomatic hypotension, particularly at initiation or dose increases. Patients with volume depletion or renal impairment are at higher risk.
How serious is the interaction between Sacubitril / valsartan and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function, and titrate each drug slowly. Reduce the tizanidine dose if symptomatic hypotension occurs.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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