Drug interactions
Sacubitril / valsartan + Torsemide
Severity: Moderate
Sacubitril / valsartan and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination is frequently used in heart failure, but excessive volume depletion can cause symptomatic hypotension and renal impairment. Valsartan can raise potassium, which may offset torsemide-related potassium loss, so electrolyte changes are unpredictable.
What this interaction means in plain words
Sacubitril / valsartan and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive and natriuretic effects, with opposing effects on serum potassium.
What to do
Monitor blood pressure, volume status, renal function and serum potassium after initiation and dose changes. Reduce the diuretic dose if hypotension or volume depletion occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Torsemide
Frequently asked questions
Can I take Sacubitril / valsartan with Torsemide?
MediHelp rates the interaction as moderate. Sacubitril / valsartan and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination is frequently used in heart failure, but excessive volume depletion can cause symptomatic hypotension and renal impairment. Valsartan can raise potassium, which may offset torsemide-related potassium loss, so electrolyte changes are unpredictable.
How serious is the interaction between Sacubitril / valsartan and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, volume status, renal function and serum potassium after initiation and dose changes. Reduce the diuretic dose if hypotension or volume depletion occurs.
What other medicines interact with Torsemide?
MediHelp also lists interactions of Torsemide with, for example, Amikacin, Amiodarone, Carbenoxolone. The full list is on the Torsemide page.
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