Drug interactions
Sacubitril-valsartan + Treprostinil
Severity: Moderate
Sacubitril-valsartan and Treprostinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents lower blood pressure through vasodilation, so using them together can produce additive hypotension. Dizziness, light-headedness or syncope may occur, especially at treatment initiation or after dose increases.
What this interaction means in plain words
Sacubitril-valsartan and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sacubitril-valsartan belongs to Cardiovascular; Treprostinil belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic vasodilatory and blood pressure-lowering effects.
What to do
Monitor blood pressure and symptoms of hypotension when starting or titrating either drug. Reduce the dose of one agent if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Sacubitril-valsartan and Treprostinil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Treprostinil
Frequently asked questions
Can I take Sacubitril-valsartan with Treprostinil?
MediHelp rates the interaction as moderate. Sacubitril-valsartan and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents lower blood pressure through vasodilation, so using them together can produce additive hypotension. Dizziness, light-headedness or syncope may occur, especially at treatment initiation or after dose increases.
How serious is the interaction between Sacubitril-valsartan and Treprostinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of hypotension when starting or titrating either drug. Reduce the dose of one agent if symptomatic hypotension develops.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
