Drug interactions
Safinamide + Selexipag
Severity: Minor
Safinamide and Selexipag: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selexipag is a BCRP substrate, and safinamide may inhibit BCRP in the gut. Selexipag exposure could increase modestly, with more prostacyclin-type adverse effects such as headache, diarrhea and jaw pain.
What this interaction means in plain words
Safinamide and Selexipag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Safinamide belongs to Central Nervous System; Selexipag belongs to Cardiovascular.
Why it happens
Inhibition of intestinal BCRP efflux by safinamide may increase selexipag absorption.
What to do
No routine dose adjustment. Monitor for increased adverse effects of selexipag.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Other interactions of Selexipag
- Gemfibrozil + Selexipag Contraindicated
- Abiraterone + Selexipag Moderate
- Apalutamide + Selexipag Moderate
- Carbamazepine + Selexipag Moderate
- Clopidogrel + Selexipag Moderate
- Cyclosporin + Selexipag Moderate
Frequently asked questions
Can I take Safinamide with Selexipag?
MediHelp rates the interaction as minor. Safinamide and Selexipag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Selexipag is a BCRP substrate, and safinamide may inhibit BCRP in the gut. Selexipag exposure could increase modestly, with more prostacyclin-type adverse effects such as headache, diarrhea and jaw pain.
How serious is the interaction between Safinamide and Selexipag?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment. Monitor for increased adverse effects of selexipag.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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