Drug interactions
Safinamide + Thioridazine
Severity: Moderate
Safinamide and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine blocks dopamine receptors and can worsen motor symptoms in Parkinson disease, opposing the benefit of safinamide. The result may be loss of symptom control and worsening rigidity or bradykinesia.
What this interaction means in plain words
Safinamide and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Safinamide belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism: dopamine D2 receptor blockade opposes dopaminergic enhancement by safinamide.
What to do
Avoid dopamine antagonists in Parkinson disease where possible; if an antipsychotic is needed use quetiapine or clozapine. Monitor motor function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Safinamide with Thioridazine?
MediHelp rates the interaction as moderate. Safinamide and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thioridazine blocks dopamine receptors and can worsen motor symptoms in Parkinson disease, opposing the benefit of safinamide. The result may be loss of symptom control and worsening rigidity or bradykinesia.
How serious is the interaction between Safinamide and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid dopamine antagonists in Parkinson disease where possible; if an antipsychotic is needed use quetiapine or clozapine. Monitor motor function.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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