Drug interactions
Safinamide + Topotecan
Severity: Moderate
Safinamide and Topotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topotecan is a BCRP substrate, and oral topotecan bioavailability depends on intestinal BCRP. Safinamide may inhibit BCRP and raise topotecan exposure, increasing the risk of myelosuppression.
What this interaction means in plain words
Safinamide and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Safinamide belongs to Central Nervous System; Topotecan belongs to Oncology.
Why it happens
Safinamide inhibits BCRP, reducing efflux and increasing topotecan absorption and exposure.
What to do
Monitor complete blood counts closely. Reduce the topotecan dose if neutropenia or thrombocytopenia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporine + Topotecan Major
- Cyclosporin + Topotecan Major
Frequently asked questions
Can I take Safinamide with Topotecan?
MediHelp rates the interaction as moderate. Safinamide and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Topotecan is a BCRP substrate, and oral topotecan bioavailability depends on intestinal BCRP. Safinamide may inhibit BCRP and raise topotecan exposure, increasing the risk of myelosuppression.
How serious is the interaction between Safinamide and Topotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely. Reduce the topotecan dose if neutropenia or thrombocytopenia develops.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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