Drug interactions
Safinamide + Tranylcypromine
Severity: Contraindicated
Safinamide and Tranylcypromine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Safinamide with a nonselective MAO inhibitor increases the risk of hypertensive crisis and serotonin syndrome. Safinamide labeling contraindicates use with other MAO inhibitors.
What this interaction means in plain words
Safinamide and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Safinamide belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
Additive MAO inhibition, including loss of MAO-B selectivity, causes excessive monoamine accumulation.
What to do
Do not co-administer. Wait at least 14 days after stopping safinamide before starting tranylcypromine, and allow the MAOI washout before starting safinamide.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Safinamide with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Safinamide and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Safinamide with a nonselective MAO inhibitor increases the risk of hypertensive crisis and serotonin syndrome. Safinamide labeling contraindicates use with other MAO inhibitors.
How serious is the interaction between Safinamide and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Wait at least 14 days after stopping safinamide before starting tranylcypromine, and allow the MAOI washout before starting safinamide.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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